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Testosterone substitution should be withheld as long as possible, since it interferes with HPG axis recovery, and prescribed only if no further recovery of the HPG is expected. Prednisone is a corticosteroid that prevents the release of substances in the body that cause inflammation. However, a second possibility is that muscles involved in performance were not adequately trained during administration of supplemental testosterone, or there was no control of exercise during the period of testosterone administration.



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